Google DeepMind’s AlphaGenome 2 Predicts Cell-State Variant Effects

Google DeepMind announced AlphaGenome 2 on November 11, 2026, a deep-learning model that predicts how DNA variants affect gene regulation in individual cell types and states. Trained on more than 100 million individual cell profiles, it is available for non-commercial research and in private preview for commercial research. The release addresses a blind spot in tissue-wide genomic models: a variant can matter only in a specialized cell or in a cell activated by disease, leaving its signal...